- Tumor histology and immunohistochemical studies:
Deep invasion is defined as invasion beyond the subcutaneous fat or greater than 6 mm (as measured from the granular layer of adjacent normal epidermis to the base of the tumor); perineural invasion for T3 classification is defined as tumor cells within the nerve sheath of a nerve lying deeper than the dermis or measuring 0.1 mm or larger in caliber, or presenting with clinical or radiographic involvement of named nerves without skull base invasion or transgression.
pN2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or in bilateral or contralateral lymph node(s), none larger than 6 cm in greatest dimension, ENE(-)
pN3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or in a single ipsilateral node larger than 3 cm in greatest dimension and ENE(+); or multiple ipsilateral, contralateral, or bilateral nodes, any with ENE(+); or a single contralateral node of any size and ENE(+)
+ High risk factors:
Tumor diameter greater than or equal to 2 cm Poorly differentiated histology Perineural invasion greater than or equal to 0.1 mm in caliber Tumor invasion beyond subcutaneous fat (excluding bone invasion, which upgrades tumor to BWH stage T3)
+ BWH Tumor Classification:
Immunosuppressed status (specify cause, if known):
- Other (specify):
- Additional notes: